July 18, 2025 #1 Local News, Information and Event Source for the Century City/Westwood areas.

Study Published Today On Therapy That Uses Salmonella Bacterium to Combat Pancreatic Cancer

ThinkstockPhotos-459886493Researchers at the City of Hope said in a study published today that they have created a therapy that uses the Salmonella bacterium to combat pancreatic ductal adenocarcinoma, an aggressive form of pancreatic cancer.

Patients with pancreatic ductal adenocarcinoma currently have few good therapeutic options, with most medications able to increase survival by only a few months while exacting a high physical toll, City of Hope said in a statement, adding that an engineered Salmonella bacterium is expected to be the exception.

In a new study in the journal Cancer Immunology Research, published by the American Association for Cancer Research, the researchers say that a specific bacterial-based therapy is able to home in on tumors and trigger “an extremely effective tumor-killing response.”

The study, involving laboratory mice, found that the therapy frequently triggered the complete regression of pancreatic tumors and significantly extended survival, the statement said.

“The results were, in a word, remarkable,” said lead researcher Don J. Diamond, Ph.D., who chairs the Department of Experimental Therapeutics at City of Hope. “This method has the potential to treat a variety of cancers that share similar features to pancreatic ductal adenocarcinoma, currently one of the most difficult-to-treat cancers and one for which we desperately need better options.”

Bacteria-based therapies have been used to treat solid tumors for decades and are commonly used to treat bladder cancer, but the success of such therapies has been limited by many tumor defenses. In the new study, Diamond and his colleagues engineered the bacterium Salmonella typhimurium to crack those defenses.

The researchers did so by transforming the bacterium to carry a piece of DNA that targets a molecule known as IDO, which camouflages cancer cells and prevents the immune system from recognizing and killing the tumor, the statement said.

in News
Related Posts

Man Arrested in Brentwood for Impersonating Firefighter During Palisades Fire

July 18, 2025

July 18, 2025

The suspect faces at least 28 criminal counts—including 23 felonies—spanning incidents from 2023 to May 2025 Federal and local law...

Study Highlights Economic Impact of Cap-and-Trade Extension in Los Angeles

July 18, 2025

July 18, 2025

Governor Gavin Newsom and legislative leaders are pushing to reauthorize the program this year, citing its role in generating 287,000...

Nearly $1B Secured for Refinancing of Westfield Century City Mall

July 17, 2025

July 17, 2025

The proceeds will replace a $925 million commercial mortgage-backed securities loan, originally issued by Morgan Stanley in 2023 and due...

West Coast Premiere of ‘The Opposite of Love’ Opens at Hudson Backstage Theatre

July 17, 2025

July 17, 2025

Produced by Neil Gooding Productions, behind shows like Back to the Future: The Musical, the play runs Thursdays through Saturdays...

Tesla Seen Nearly Crashing into West LA Home After Collision

July 17, 2025

July 17, 2025

Footage depicted a blue Prius on the road with significant front-end damage A crash involving injuries was reported around 12:30...

DUI Checkpoints to be Conducted Across LA This Weekend

July 16, 2025

July 16, 2025

The LAPD selects checkpoint sites based on data indicating high incidents of impaired driving-related crashes and arrests The Los Angeles...

Mayor Bass Hails National Guard Withdrawal as Victory for Unity

July 16, 2025

July 16, 2025

The Pentagon’s decision to reduce the troop presence follows weeks of legal challenges and public demonstrations Mayor Karen Bass celebrated...

(Video) Did You Know Emma Chamberlain’s Coffee Shop is in Century City?

July 16, 2025

July 16, 2025

The outpost is a first for the popular influencer Did You Know Emma Chamberlain’s Coffee Shop is in Century City?...

Dodgers to Host Back to School Bash for Fire-Affected Families

July 16, 2025

July 16, 2025

The free event will offer free groceries, school supplies, outfits, haircuts, medical screenings, and carnival rides The Los Angeles Dodgers...

Hundreds of Red-Legged Frog Tadpoles Released in Santa Monica Mountains

July 16, 2025

July 16, 2025

Once widespread in California, red-legged frogs vanished from the Santa Monica Mountains by the 1970s Nearly 600 California red-legged frog...

LA Sees Second Straight Year of Homelessness Decline, Leaders Celebrate Progress

July 16, 2025

July 16, 2025

The survey, designed by the University of Southern California, reported a 17.5% drop—the largest two-year decrease on record The Los...

Westwood Village Board to Discuss Public Art Initiative

July 15, 2025

July 15, 2025

The initiative aims to enhance community pride, boost local business revenue, and address urban blight through public art corridors and...

Beverly Hills Plans Major Apartment Development Near Civic Center

July 15, 2025

July 15, 2025

The site, currently holding 13 residential units, is slated for demolition to make way for the new development A proposal...

Federal Judge Sides with Santa Monica, Other Local Governments Against Immigration Raids

July 15, 2025

July 15, 2025

Santa Monica Mayor Lana Negrete praised the ruling, saying it reaffirmed the city’s commitment to protecting residents from unjust detention...

California Hits Two-Thirds Clean Energy Milestone

July 15, 2025

July 15, 2025

This year, clean energy has powered the state for an average of seven hours daily, with over 90% of days...